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Article

Modulation of gene activity by consecutive gene targeting of one creatine kinase M allele in mouse embryonic stem cells.

Nucleic acids research - 25 May 1991

van Deursen J, Lovell-Badge R, Oerlemans F, Schepens J, Wieringa B

Abstract excerpt

The cytosolic creatine kinases (CK's; EC 2.7.3.2) BB, BM and MM are dimeric isoenzymes which have an important role in energy metabolism and display characteristic tissue- and stage-specific patterns of expression in mammals. To study the functional role of the distribution of the CK isoenzymes we have focussed on the modulation of expression of the genes encoding the individual B and M subunits, starting at the...

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Identifiers

PMID: 2041741
DOI: 10.1093/nar/19.10.2637
PMCID: PMC328181

Genes

CKM
CKB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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