Article
Modulation of gene activity by consecutive gene targeting of one creatine kinase M allele in mouse embryonic stem cells.
Nucleic acids research - 25 May 1991
van Deursen J, Lovell-Badge R, Oerlemans F, Schepens J, Wieringa B
Abstract excerpt
The cytosolic creatine kinases (CK's; EC 2.7.3.2) BB, BM and MM are dimeric isoenzymes which have an important role in energy metabolism and display characteristic tissue- and stage-specific patterns of expression in mammals. To study the functional role of the distribution of the CK isoenzymes w...
Topics
- Alleles
- Animals
- Cell Line
- Cloning, Molecular
- Creatine Kinase
- Drug Resistance
- Gene Expression Regulation
- Genetic Techniques
- Isoenzymes
- Male
- Mice
- Muscles
- Neomycin
- Plasmids
- Restriction Mapping
- Stem Cells