Article
Confirmation of mutant alpha 1 Na,K-ATPase gene and transcript in Dahl salt-sensitive/JR rats.
Hypertension (Dallas, Tex. : 1979) - 1 Sept 1994
Ruiz-Opazo N, Barany F, Hirayama K, Herrera V L
Abstract excerpt
As the sole renal Na,K-ATPase isozyme, the alpha 1 Na,K-ATPase accounts for all active transport of Na+ throughout the nephron. This role in renal Na+ reabsorption and the primacy of the kidney in hypertension pathogenesis make it a logical candidate gene for salt-sensitive genetic hypertension....
Topics
- Alleles
- Animals
- Base Sequence
- DNA, Complementary
- Drug Resistance
- Genes
- Genetic Techniques
- Ligases
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Rats
- Rats, Inbred Strains
- Sodium Chloride
- Sodium-Potassium-Exchanging ATPase
- Transcription, Genetic