Nitric oxide recombination to double mutants of myoglobin: role of ligand diffusion in a fluctuating heme pocket.

doi:10.1021/bi00201a005

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Article

Nitric oxide recombination to double mutants of myoglobin: role of ligand diffusion in a fluctuating heme pocket.

Biochemistry - 6 Sept 1994

Carlson M L, Regan R, Elber R, Li H, Phillips G N, Olson J S, Gibson Q H

Abstract excerpt

Picosecond recombination of nitric oxide to the double mutants of myoglobin, His64Gly-Val68Ala and His64Gly.Val68Ile, at E7 and E11, has been studied experimentally and by computation. It is shown that distal residues have a profound effect on NO recombination. Recombination in the mutants may be...

Topics

Amino Acid Sequence
Diffusion
Heme
Ligands
Models, Molecular
Molecular Sequence Data
Mutation
Myoglobin
Nitric Oxide
Recombinant Proteins
Structure-Activity Relationship

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