Article
Human myoglobin recognition of oxygen: dynamics of the energy landscape.
Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2004
Wang Yuhong, Baskin J Spencer, Xia Tianbing, Zewail Ahmed H
Abstract excerpt
Femtosecond to nanosecond dynamics of O(2) rebinding to human WT myoglobin and its mutants, V68F and I107F, have been studied by using transient absorption. The results are compared with NO rebinding. Even though the immediate environment around the heme binding site is changed by the mutations, the picosecond geminate rebinding of oxygen is at most minimally affected. On the other hand, the V68F (E11) mutation...
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