Dominant negative mutator mutations in the mutS gene of Escherichia coli.

doi:10.1128/jb.176.17.5393-5400.1994

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Article

Dominant negative mutator mutations in the mutS gene of Escherichia coli.

Journal of bacteriology - 1 Sept 1994

Wu T H, Marinus M G

Abstract excerpt

The MutS protein of Escherichia coli is part of the dam-directed MutHLS mismatch repair pathway which rectifies replication errors and which prevents recombination between related sequences. In order to more fully understand the role of MutS in these processes, dominant negative mutS mutations on a multicopy plasmid were isolated by screening transformed wild-type cells for a mutator phenotype, using a Lac+...

Topics

Adenosine Triphosphatases
Alleles
Amino Acid Sequence
Bacterial Proteins
Binding Sites
DNA Repair
DNA, Bacterial
DNA-Binding Proteins
Drug Resistance, Microbial
Escherichia coli
Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Bacterial

Genes, Dominant

Genetic Complementation Test

Hydroxylamine

Hydroxylamines

Molecular Sequence Data

MutS DNA Mismatch-Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 8071216
DOI: 10.1128/jb.176.17.5393-5400.1994
PMCID: PMC196726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8071216-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Dominant negative mutator mutations in the mutS gene of Escherichia coli.PMID 8071216Read ↗

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