Article
Dominant negative mutator mutations in the mutS gene of Escherichia coli.
Journal of bacteriology - 1 Sept 1994
Wu T H, Marinus M G
Abstract excerpt
The MutS protein of Escherichia coli is part of the dam-directed MutHLS mismatch repair pathway which rectifies replication errors and which prevents recombination between related sequences. In order to more fully understand the role of MutS in these processes, dominant negative mutS mutations on a multicopy plasmid were isolated by screening transformed wild-type cells for a mutator phenotype, using a Lac+...
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