Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular analysis of mutS expression and mutation in natural isolates of pathogenic Escherichia coli.

Microbiology (Reading, England) - 1 May 2003

Li Baoguang, Tsui Ho-Ching T, LeClerc J Eugene, Dey Manashi, Winkler Malcolm E, Cebula Thomas A

Abstract excerpt

Deficiencies in the MutS protein disrupt methyl-directed mismatch repair (MMR), generating a mutator phenotype typified by high mutation rates and promiscuous recombination. How such deficiencies might arise in the natural environment was determined by analysing pathogenic strains of Escherichia coli. Quantitative Western immunoblotting showed that the amount of MutS in a wild-type strain of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Base Pair Mismatch

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to Escherichia coli Infections

Share to Escherichia coli O157

Share to Escherichia coli Proteins

Share to Gene Expression Regulation, Bacterial

Share to MutS DNA Mismatch-Binding Protein

Source

Identifiers

PMID: 12724393
DOI: 10.1099/mic.0.26213-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular analysis of mutS expression and mutation in natural isolates of pathogenic Escherichia coli.PMID 12724393Read ↗

Dominant negative mutator mutations in the mutS gene of Escherichia coli.Semantic proximity Read ↗

Phylogenetic evidence for horizontal transfer of mutS alleles among naturally occurring Escherichia coli strains.Semantic proximity Read ↗

The Helicobacter pylori MutS protein confers protection from oxidative DNA damageSemantic proximity Read ↗

High mutation frequencies among Escherichia coli and Salmonella pathogens.Semantic proximity Read ↗

Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low.Semantic proximity Read ↗

Distribution of mutation frequencies among Salmonella enterica isolates from animal and human sources and genetic characterization of a Salmonella Heidelberg hypermutator.Semantic proximity Read ↗

The MutS C terminus is essential for mismatch repair activity in vivo.Semantic proximity Read ↗

Deletion mutation analysis of the mutS gene in Escherichia coli.Semantic proximity Read ↗

The role of mutators in the emergence of antibiotic-resistant bacteria.Semantic proximity Read ↗

Hypermutable bacteria isolated from humans--a critical analysis.Semantic proximity Read ↗

Mutators Enhance Adaptive Micro-Evolution in Pathogenic MicrobesSemantic proximity Read ↗

Negative regulation of mutS and mutH repair gene expression by the Hfq and RpoS global regulators of Escherichia coli K-12Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.