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Article

Developmentally regulated excision of a 28-base-pair sequence from the Paramecium genome requires flanking DNA.

Molecular and cellular biology - 1 Nov 2000

Ku M, Mayer K, Forney J D

Abstract excerpt

The micronuclear DNA of Paramecium tetraurelia is estimated to contain over 50,000 short DNA elements that are precisely removed during the formation of the transcriptionally active macronucleus. Each internal eliminated sequence (IES) is bounded by 5'-TA-3' dinucleotide repeats, a feature common to some classes of DNA transposons. We have developed an in vivo assay to analyze these highly efficient and precise...

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Identifiers

PMID: 11046136
DOI: 10.1128/MCB.20.22.8390-8396.2000
PMCID: PMC102146

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Source receipt: pubmed, retrieved 7 Sept 2026.

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