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Article

27-hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype.

Oncology reports - 1 Aug 2011

Torres Cristian G, Ramírez María E, Cruz Pamela, Epuñan María J, Valladares Luis E, Sierralta Walter D

Abstract excerpt

A decrease in the expression of E-cadherin and β-catenin, paralleling the loss of adherens junction complex, was observed in MCF7 cells exposed for longer than 48 h to 2 µM 27-hydroxycholesterol (27OHC), indicating an epithelial-mesenchymal transition (EMT). Upon removal of 27OHC from the culture medium, the cells released by the exposure of 72 h to the oxysterol grew as loosely packed cell groups. In these...

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Identifiers

PMID: 21567091
DOI: 10.3892/or.2011.1284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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