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Article

Optimal salt bridge for Trp-cage stabilization.

Biochemistry - 22 Feb 2011

Williams D Victoria, Byrne Aimee, Stewart James, Andersen Niels H

Abstract excerpt

Gai and co-workers [Bunagan, M. R., et al. (2006) J. Phys. Chem. B 110, 3759-3763] reported computational design studies suggesting that a D9E mutation would stabilize the Trp-cage. Experimental studies for this mutation were reported in 2008 [Hudaky, P., et al. (2008) Biochemistry 47, 1007-1016]; the authors suggested that [D9E]-TC5b presented a more compact and melting resistant structure because of the...

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PMID: 21222485
DOI: 10.1021/bi101555y
PMCID: PMC3111457

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