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Article

The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.

1 Apr 1994

Abstract excerpt

During Caenorhabditis elegans vulval development, an inductive signal from the anchor cell stimulates three of the six vulval precursor cells (VPCs) to adopt vulval rather than nonvulval epidermal fates. Genes necessary for this induction include the lin-3 growth factor, the let-23 receptor tyrosine kinase, and let-60 ras. lin-15 is a negative regulator of this inductive pathway. In lin-15 mutant animals, all six...

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Identifiers

PMID: 8054684
DOI: 10.1091/mbc.5.4.395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.PMID 8054684Read ↗

lin-25, a gene required for vulval induction in Caenorhabditis elegans.Semantic proximity Read ↗

Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.Semantic proximity Read ↗

Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis.Semantic proximity Read ↗

The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans.Semantic proximity Read ↗

sli-3 negatively regulates the LET-23/epidermal growth factor receptor-mediated vulval induction pathway in Caenorhabditis elegans.Semantic proximity Read ↗

Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10.Semantic proximity Read ↗

The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins.Semantic proximity Read ↗

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.Semantic proximity Read ↗

A cell-specific enhancer that specifieslin-3expression in theC. elegansanchor cell for vulval developmentSemantic proximity Read ↗

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Role of a raf proto-oncogene during Caenorhabditis elegans vulval development.Semantic proximity Read ↗

Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development.Semantic proximity Read ↗

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