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Alzheimer's disease. Clinical molecular genetics.

Clinics in geriatric medicine - 1 May 1994

Hardy J

Abstract excerpt

The study of the genetics of AD has shown that at least three loci are involved in causing the disease: (1) the APP gene, in which a series of mutations cause the disease to develop in 50- to 60-year-old patients; (2) the ApoE gene in which genetic variability (the E4 allele) is a predisposing factor for the development of late-onset disease; and (3) an as-yet-unidentified chromosome 14 locus that causes the...

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PMID: 8039096

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APP

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