Article
Mutations in LIS1 (ERG6) gene confer increased sodium and lithium uptake in Saccharomyces cerevisiae.
Biochimica et biophysica acta - 13 Jul 1994
Welihinda A A, Beavis A D, Trumbly R J
Abstract excerpt
A Saccharomyces cerevisiae mutant, lis1-1, hypersensitive to Li+ and Na+ was isolated from a wild-type strain after ethylmethane sulfonate mutagenesis. The rates of Li+ and Na+ uptake of the mutant are about 3-4-times higher than that of the wild-type; while the rates of cation efflux from the mutant and wild-type strains are indistinguishable. The LIS1 was isolated from a yeast genomic library by complementation...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Base Sequence
- Biological Transport
- Cations
- Cloning, Molecular
- Genes, Fungal
- Lithium
- Molecular Sequence Data
- Mutation
- Saccharomyces cerevisiae