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Article

HOL1 mutations confer novel ion transport in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Feb 1990

Gaber R F, Kielland-Brandt M C, Fink G R

Abstract excerpt

Saccharomyces cerevisiae histidine auxotrophs are unable to use L-histidinol as a source of histidine even when they have a functional histidinol dehydrogenase. Mutations in the hol1 gene permit growth of His- cells on histidinol by enhancing the ability of cells to take up histidinol from the medium. Second-site mutations linked to HOL1-1 further increase histidinol uptake. HOL1 double mutants and, to a lesser...

Topics

Alcohol Oxidoreductases
Chromosome Deletion
Cloning, Molecular
DNA, Fungal
Genes, Dominant
Genes, Fungal
Genotype
Heterozygote
Histidine
Histidinol
Kinetics
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Restriction Mapping

Saccharomyces cerevisiae

Sodium

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Identifiers

PMID: 2405251
DOI: 10.1128/mcb.10.2.643-652.1990
PMCID: PMC360862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2405251-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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