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Article

HOL1 mutations confer novel ion transport in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Feb 1990

Gaber R F, Kielland-Brandt M C, Fink G R

Abstract excerpt

Saccharomyces cerevisiae histidine auxotrophs are unable to use L-histidinol as a source of histidine even when they have a functional histidinol dehydrogenase. Mutations in the hol1 gene permit growth of His- cells on histidinol by enhancing the ability of cells to take up histidinol from the medium. Second-site mutations linked to HOL1-1 further increase histidinol uptake. HOL1 double mutants and, to a lesser...

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Identifiers

PMID: 2405251
DOI: 10.1128/mcb.10.2.643-652.1990
PMCID: PMC360862

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