Article
Natural Variation in the Multidrug Efflux Pump SGE1 Underlies Ionic Liquid Tolerance in Yeast.
Genetics - 1 Sept 2018
Higgins Douglas A, Young Megan K M, Tremaine Mary, Sardi Maria, Fletcher Jenna M, Agnew Margaret, Liu Lisa, Dickinson Quinn, Peris David, Wrobel Russell L, Hittinger Chris Todd, Gasch Audrey P, Singer Steven W, Simmons Blake A, Landick Robert, Thelen Michael P, Sato Trey K
Abstract excerpt
Imidazolium ionic liquids (IILs) have a range of biotechnological applications, including as pretreatment solvents that extract cellulose from plant biomass for microbial fermentation into sustainable bioenergy. However, residual levels of IILs, such as 1-ethyl-3-methylimidazolium chloride ([C2C1im]Cl), are toxic to biofuel-producing microbes, including the yeast Saccharomyces cerevisiae. S. cerevisiae strains...
Topics
- Drug Tolerance
- Genetic Variation
- Imidazoles
- Ionic Liquids
- Membrane Proteins
- Membrane Transport Proteins
- Phenotype
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins