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Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients

9 Feb 2016

Abstract excerpt

OBJECTIVE: Hereditary spastic paraplegias (HSPs) are genetically driven disorders with the hallmark of progressive spastic gait disturbance. To investigate the phenotypic spectrum, prognostic factors, and genotype-specific differences, we analyzed baseline data from a continuous, prospective cohort. METHODS: We recruited 608 HSP cases from 519 families of mostly German origin. Clinical severity was assessed by...

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PMID: 26856398
DOI: 10.1002/ana.24611

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