Article
Immunogenicity testing of diphtheria and tetanus vaccines by using isogenic mice with possible implications for potency testing.
Laboratory animals - 1 Apr 1994
Hendriksen C F, Slob W, vd Gun J W, Westendorp J H, den Bieman M, Hesp A, van Zutphen L F
Abstract excerpt
The antitoxin response of isogenic mice (inbred strains and F1 hybrids), immunized with diphtheria and tetanus reference vaccines, was compared with the response of animals from an NIH outbred stock. The variance in antitoxin response was smaller within the groups of isogenic mice than within the group of mice from the outbred strain. The case for estimating the potency of diphtheria and tetanus vaccines by using...
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