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Article

Roles of electrophilic sulfuric acid ester metabolites in mutagenesis and carcinogenesis by some polynuclear aromatic hydrocarbons.

Chemico-biological interactions - 1 Jun 1994

Surh Y J, Miller J A

Abstract excerpt

Hydroxylation of meso-methyl groups with subsequent formation of reactive benzylic esters bearing a good leaving group (e.g. sulfate) was proposed as a possible biochemical mechanism of activation and tumorigenicity of methyl-substituted polycyclic aromatic hydrocarbons (PAHs). In support of this postulation, recent studies have demonstrated the formation by rodent hepatic sulfotransferase activity of...

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PMID: 8033269
DOI: 10.1016/0009-2797(94)90076-0

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