Article
Roles of electrophilic sulfuric acid ester metabolites in mutagenesis and carcinogenesis by some polynuclear aromatic hydrocarbons.
Chemico-biological interactions - 1 Jun 1994
Surh Y J, Miller J A
Abstract excerpt
Hydroxylation of meso-methyl groups with subsequent formation of reactive benzylic esters bearing a good leaving group (e.g. sulfate) was proposed as a possible biochemical mechanism of activation and tumorigenicity of methyl-substituted polycyclic aromatic hydrocarbons (PAHs). In support of this postulation, recent studies have demonstrated the formation by rodent hepatic sulfotransferase activity of...
Topics
- Animals
- Biotransformation
- Carcinogens
- DNA
- Esters
- Hydroxylation
- Liver
- Mutagens
- Mutation
- Polycyclic Compounds
- Sulfotransferases