Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanisms for the regulation of aryl sulfotransferase IV expression during 2-acetylaminofluorene-induced hepatocarcinogenesis in rat.

Chemico-biological interactions - 1 Jun 1994

Ringer D P, Yerokun T, Khan A S

Abstract excerpt

The dietary administration of 2-acetylaminofluorene to male rats to induce hepatocarcinogenesis causes a reversible as well as persistent down-modulation of N-hydroxy-2AAF sulfotransferase activity. Studies are presented which indicate that several molecular mechanisms may be involved in the down-regulation of sulfotransferase activity and expression. These include carcinogen-mediated inactivation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down-Regulation
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hormones

Share to Liver Neoplasms, Experimental

Share to Mutation

Share to RNA, Messenger

Source

Identifiers

PMID: 8033268
DOI: 10.1016/0009-2797(94)90075-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Molecular mechanisms for the regulation of aryl sulfotransferase IV expression during 2-acetylaminofluorene-induced hepatocarcinogenesis in rat.PMID 8033268Read ↗

The role of acetylator genotype on hepatic and extrahepatic acetylation, deacetylation, and sulfation of 2-aminofluorene, 2-acetylaminofluorene, and N-hydroxy-2-acetylaminofluorene in the inbred hamster.Semantic proximity Read ↗

Hprt lymphocyte mutant frequency in relation to DNA adduct formation in rats fed the hepatocarcinogen 2-acetylaminofluorene.Semantic proximity Read ↗

Androgen receptor-mediated genetic differences in 2-acetylaminofluorene and dimethylnitrosamine mutagenesis in vitro.Semantic proximity Read ↗

Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression.Semantic proximity Read ↗

Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas.Semantic proximity Read ↗

Role of epigenetic and miR‐22 and miR‐29b alterations in the downregulation of <i>Mat1a</i> and <i>Mthfr</i> genes in early preneoplastic livers in rats induced by 2‐acetylaminofluoreneSemantic proximity Read ↗

Regulation of arylamine N-acetyltransferases.Semantic proximity Read ↗

Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.