Article
Antigenic drift of non‐encapsulated <i>Haemophilus influenzae</i> major outer membrane protein P2 in patients with chronic bronchitis is caused by point mutations
1 Mar 1994
Abstract excerpt
The sequence of the gene encoding major outer membrane protein (MOMP) P2 of antigenic variants of non-encapsulated Haemophilus influenzae isolated from persistently infected chronic bronchitis patients was analysed. Antigenic drift was shown to result from single base changes in the P2 gene, all generating amino acid changes in the surface-exposed loops of MOMP P2, predominantly in loop 6. Similar single base...