Article
Human antibody responses to Pfs 230, a sexual stage-specific surface antigen of Plasmodium falciparum: non-responsiveness is a stable phenotype but does not appear to be genetically regulated.
Parasite immunology - 1 Feb 1994
Riley E M, Bennett S, Jepson A, Hassan-King M, Whittle H, Olerup O, Carter R
Abstract excerpt
The 230 kD gamete surface protein of the malaria parasite Plasmodium falciparum (Pfs 230) is a target of transmission blocking antibodies. Anti-Pfs 230 antibodies are induced following natural infection with malaria but are not found in all P. falciparum-exposed individuals. In this study we have shown that approximately 40% of malaria-exposed Gambians do not make antibodies to the native Pfs 230 molecule. This...
Topics
- Adolescent
- Adult
- Animals
- Antibodies, Protozoan
- Antigens, Protozoan
- Antigens, Surface
- Child
- Child, Preschool
- Gambia
- Genotype
- HLA-D Antigens