Article
Separate P2T and P2U purinergic receptors with similar second messenger signaling pathways in UMR-106 osteoblasts.
The Journal of pharmacology and experimental therapeutics - 1 Jun 1994
Sistare F D, Rosenzweig B A, Contrera J G, Jordan B
Abstract excerpt
UMR-106 rat osteogenic sarcoma cells express two calcium signaling P2 purinergic receptors. One is a P2U receptor with EC50's for adenosine triphosphate (ATP) and uridine triphosphate (UTP) of 2.6 and 2.4 microM, respectively. The other is a novel P2T receptor for adenosine diphosphate (ADP) (EC50 0.4 microM), adenosine 5'-O-(2-thiodiphosphate). (EC50 5 microM), 2-methylthio ATP (EC50 0.2 microM), and...
Topics
- Adenosine Diphosphate
- Adenosine Monophosphate
- Adenosine Triphosphate
- Animals
- Calcium
- Cyclic AMP
- Dose-Response Relationship, Drug
- Inositol 1,4,5-Trisphosphate
- Osteoblasts
- Osteosarcoma
- Phenotype