Article
P2X(1) and P2X(3) purinergic receptors differentially modulate the inflammatory response in human osteoarthritic synovial fibroblasts.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2010
Varani Katia, De Mattei Monica, Vincenzi Fabrizio, Tosi Alice, Targa Martina, Masieri Federica F, Pellati Agnese, Massari Leo, Borea Pier Andrea
Abstract excerpt
BACKGROUND/AIMS: P2X receptors are membrane ion channels activated by extracellular adenosine 5'-triphosphate (ATP) which contribute to various physiological processes. The present study describes in synovial fibroblasts (SFs) obtained from osteoarthritis (OA) patients and in SW 982 cells derived from human synovial sarcoma a pharmacological characterization of P2X(1) and P2X(3) receptors implicated in the...
Topics
- Cell Line
- Dinoprostone
- Fibroblasts
- Humans
- Inflammation Mediators
- Interleukin-6
- NF-kappa B
- Osteoarthritis
- Phenotype
- Protein Binding
- Receptors, Purinergic P2
- Receptors, Purinergic P2X