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Article

Adenine nucleotides decrease the apparent Km of endogenous natriuretic peptide receptors for GTP.

American journal of physiology. Endocrinology and metabolism - 1 Dec 2007

Antos Laura K, Potter Lincoln R

Abstract excerpt

Natriuretic peptide receptors A (NPR-A) and B (NPR-B) mediate most effects of natriuretic peptides by synthesizing cGMP. ATP increases the activity of these receptors by an unknown mechanism. We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for the activation of NPR-A and NPR-B in membranes from highly overexpressing cells. Here, we...

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PMID: 17848634
DOI: 10.1152/ajpendo.00321.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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