Article
Role of ecto-NTPDases on UDP-sensitive P2Y(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women.
Journal of cellular physiology - 1 Jun 2012
Noronha-Matos J B, Costa M A, Magalhães-Cardoso M T, Ferreirinha F, Pelletier J, Freitas R, Neves J M, Sévigny J, Correia-de-Sá P
Abstract excerpt
This study aimed at investigating the expression and function of uracil nucleotide-sensitive receptors (P2Y(2), P2Y(4), and P2Y(6)) on osteogenic differentiation of human bone marrow stromal cells (BMSCs) in culture. Bone marrow specimens were obtained from postmenopausal female patients (68 ± 5 years old, n = 18) undergoing total hip arthroplasty. UTP and UDP (100 µM) facilitated osteogenic differentiation of...
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