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Article

Mutations in B-type natriuretic peptide mediating receptor-A selectivity.

FEBS letters - 8 Sept 1997

Schoenfeld J R, Tom J Y, Lowe D G

Abstract excerpt

Libraries of monovalent display-phage expressing mutant human B-type natriuretic peptide (hBNP) were used to identify variants that preferentially bind natriuretic peptide receptor-A (NPR-A) compared to receptor-C (NPR-C). Position 19 was a significant determinant of receptor specificity for hBNP display phage. The synthetic hBNP variant S19R had a 265-fold improved NPR-A binding over NPR-C, analogous to the...

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PMID: 9315698
DOI: 10.1016/s0014-5793(97)00956-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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