Article
Ligand-independent oligomerization of natriuretic peptide receptors. Identification of heteromeric receptors and a dominant negative mutant.
The Journal of biological chemistry - 15 Sept 1992
Chinkers M, Wilson E M
Abstract excerpt
Activation of many single-transmembrane receptors requires ligand-induced receptor oligomerization. We have examined the oligomerization of the atrial natriuretic peptide receptor, NPR-A, using epitope-tagged receptor in a co-immunoprecipitation assay. Unlike other single-transmembrane receptors,...
Topics
- Amino Acid Sequence
- Atrial Natriuretic Factor
- Cells, Cultured
- Cyclic GMP
- Epitopes
- Ligands
- Molecular Sequence Data
- Mutation
- Plasmids
- Precipitin Tests
- Receptors, Atrial Natriuretic Factor
- Receptors, Cell Surface
- Transfection