Article
Nerve growth factor directs differentiation of the bipotential cell line GH-3 into the mammotroph phenotype.
Endocrinology - 1 Jul 1994
Missale C, Boroni F, Sigala S, Zanellato A, Dal Toso R, Balsari A, Spano P
Abstract excerpt
GH-3 is an established cell line which, for the production of both PRL and GH, may be related to the bipotential somatomammotroph from which both somatotroph and mammotroph cells derive. In the present study we first report that GH-3 cells express both the gp140trk and the gp75 components of the...
Topics
- Cell Differentiation
- Fluorescent Antibody Technique
- Growth Hormone
- Membrane Glycoproteins
- Nerve Growth Factors
- Peptide Fragments
- Phenotype
- Pituitary Gland, Anterior
- Prolactin
- Proto-Oncogene Proteins
- Receptor Protein-Tyrosine Kinases