Article
Nerve growth factor suppresses the transforming phenotype of human prolactinomas.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1993
Missale C, Boroni F, Losa M, Giovanelli M, Zanellato A, Dal Toso R, Balsari A, Spano P
Abstract excerpt
The most effective therapy of human prolactinomas is represented by dopamine D-2 receptor agonists; there is, however, a population of nonresponder patients who require surgical intervention. In the present study, we report that prolactinomas totally resistant to pharmacological therapy have a high potential of both growing in soft agar and forming tumors in nude mice and lack D-2 receptors for dopamine. These...
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