Article
Nerve growth factor suppresses the transforming phenotype of human prolactinomas.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1993
Missale C, Boroni F, Losa M, Giovanelli M, Zanellato A, Dal Toso R, Balsari A, Spano P
Abstract excerpt
The most effective therapy of human prolactinomas is represented by dopamine D-2 receptor agonists; there is, however, a population of nonresponder patients who require surgical intervention. In the present study, we report that prolactinomas totally resistant to pharmacological therapy have a hi...
Topics
- Animals
- Binding, Competitive
- Bromocriptine
- Cell Division
- Cell Membrane
- Humans
- Kinetics
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Nerve Growth Factors
- Phenotype
- Pituitary Neoplasms
- Prolactin
- Prolactinoma
- Proto-Oncogene Proteins
- Receptor Protein-Tyrosine Kinases
- Receptor, trkA