Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low-Km aldehyde dehydrogenase deficiency does not influence the elevation of blood pressure by alcohol.

Journal of human hypertension - 1 Mar 1994

Okayama A, Ueshima H, Yamakawa M, Kita Y

Abstract excerpt

Increased alcohol consumption causes hypertension and leads to higher death rates by hemorrhagic strokes. About half of the Japanese population have inactive low Km aldehyde dehydrogenase (ALDH2), which metabolizes acetaldehyde to acetic acid at very low concentrations, leading to severe pharmacological effects of aldehyde when drinking alcohol. We determined persons with inactive ALDH2 using a ethanol patch...

Topics

Adult
Alcohol Drinking
Aldehyde Dehydrogenase
Blood Pressure
Ethanol
Humans
Isoenzymes
Male
Middle Aged
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8006921

Genes

ALDH2
DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8006921-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low-Km aldehyde dehydrogenase deficiency does not influence the elevation of blood pressure by alcohol.PMID 8006921Read ↗

Inactive aldehyde dehydrogenase 2 worsens glycemic control in patients with type 2 diabetes mellitus who drink low to moderate amounts of alcohol.Semantic proximity Read ↗

Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice.Semantic proximity Read ↗

Polymorphisms of ethanol-oxidizing enzymes in alcoholics with inactive ALDH2.Semantic proximity Read ↗

Validation of Alcohol Flushing Questionnaires in Determining Inactive Aldehyde Dehydrogenase-2 and Its Clinical Implication in Alcohol-Related Diseases.Semantic proximity Read ↗

Clinical characteristics and disease course of alcoholics with inactive aldehyde dehydrogenase-2.Semantic proximity Read ↗

[ALDH phenotype in eating disorders with and without alcoholism].Semantic proximity Read ↗

Reliability of a flushing questionnaire and the ethanol patch test in screening for inactive aldehyde dehydrogenase-2 and alcohol-related cancer risk.Semantic proximity Read ↗

Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2.Semantic proximity Read ↗

The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese.Semantic proximity Read ↗

Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population.Semantic proximity Read ↗

Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular volume in Japanese workers.Semantic proximity Read ↗

ALDH2 polymorphism and biological monitoring of toluene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.