Clinical characteristics and disease course of alcoholics with inactive aldehyde dehydrogenase-2.

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Article

Clinical characteristics and disease course of alcoholics with inactive aldehyde dehydrogenase-2.

Alcoholism, clinical and experimental research - 1 Apr 1998

Murayama M, Matsushita S, Muramatsu T, Higuchi S

Abstract excerpt

Inactive aldehyde dehydrogenase-2 (ALDH2) is known as a genetic negative risk factor for the development of alcoholism. In alcoholics with inactive ALDH2, unidentified factors that overcome the adverse reactions of high blood acetaldehyde concentration after drinking may increase such persons' susceptibility to alcoholism. Comparison of clinical characteristics, including sociofamilial backgrounds and...

Topics

Acetaldehyde
Adult
Aged
Alcoholism
Aldehyde Dehydrogenase
Aldehyde Dehydrogenase, Mitochondrial
Ethanol
Female
Gene Frequency
Genotype
Humans
Japan
Male
Middle Aged
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 9581663

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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