Detection of allelic loss within the beta 1-interferon gene in childhood acute lymphoblastic leukemia using differential PCR.

doi:10.1007/BF01834362

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Article

Detection of allelic loss within the beta 1-interferon gene in childhood acute lymphoblastic leukemia using differential PCR.

Annals of hematology - 1 Apr 1994

Schmidt C A, Neubauer A, Seeger K H, Rochlitz C F, Binder T, Oettle H, Henze G, Liu E T, Huhn D, Siegert W

Abstract excerpt

Deletion of the short arm of chromosome 9p involving the beta 1-interferon (IFN) gene has been implicated in the process of malignant transformation in lymphomas and acute lymphoblastic leukemias. Since cytogenetic analysis is frequently unsuccessful in clinical samples, we used a recently descri...

Topics

Acute Disease
Adult
Alleles
Child
Chromosome Deletion
Humans
Interferon-beta
Leukemia, Myeloid
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed

Identifiers

PMID: 8003558
DOI: 10.1007/BF01834362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8003558-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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