Article
Detection of allelic loss within the beta 1-interferon gene in childhood acute lymphoblastic leukemia using differential PCR.
Annals of hematology - 1 Apr 1994
Schmidt C A, Neubauer A, Seeger K H, Rochlitz C F, Binder T, Oettle H, Henze G, Liu E T, Huhn D, Siegert W
Abstract excerpt
Deletion of the short arm of chromosome 9p involving the beta 1-interferon (IFN) gene has been implicated in the process of malignant transformation in lymphomas and acute lymphoblastic leukemias. Since cytogenetic analysis is frequently unsuccessful in clinical samples, we used a recently described differential PCR technique to detect losses within the beta 1-IFN gene in 86 acute leukemias. Using differential...
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