Article
Novel variants of human IFN-alpha detected in tumor cell lines and biopsy specimens.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Oct 1997
Golovleva I, Biasotto M, Verpy E, Roos G, Meo T, Tosi M, Lundgren E
Abstract excerpt
Interferon-alpha constitutes a complex gene family with 14 genes clustered on the short arm of chromosome 9. More than 50 sequence variants have been described. However, an extensive genetic polymorphism has not been seen in the few population studies reported so far. As many of the sequence vari...
Topics
- Biopsy
- Carcinoma, Renal Cell
- Chromosome Mapping
- Genetic Variation
- Humans
- Interferon-alpha
- Kidney Neoplasms
- Leukemia
- Multigene Family
- Mutation
- Polymorphism, Restriction Fragment Length
- Tumor Cells, Cultured