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Article

Subcellular relocalization of a long-chain fatty acid CoA ligase by a suppressor mutation alleviates a respiration deficiency in Saccharomyces cerevisiae.

The EMBO journal - 1 Dec 1994

Harington A, Schwarz E, Slonimski P P, Herbert C J

Abstract excerpt

We have isolated an extragenic suppressor, FAM1-1, which is able to restore respiratory growth to a deletion of the CEM1 gene (mitochondrial beta-keto-acyl synthase). The sequence of the suppressor strongly suggests that it encodes a long-chain fatty acid CoA ligase (fatty-acyl-CoA synthetase). We have also cloned and sequenced the wild-type FAM1 gene, which is devoid of suppressor activity. The comparison of the...

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Identifiers

PMID: 7988550
DOI: 10.1002/j.1460-2075.1994.tb06890.x
PMCID: PMC395515

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