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Article

Defects in mitochondrial fatty acid synthesis result in failure of multiple aspects of mitochondrial biogenesis in Saccharomyces cerevisiae.

Molecular microbiology - 1 Nov 2013

Kursu V A Samuli, Pietikäinen Laura P, Fontanesi Flavia, Aaltonen Mari J, Suomi Fumi, Raghavan Nair Remya, Schonauer Melissa S, Dieckmann Carol L, Barrientos Antoni, Hiltunen J Kalervo, Kastaniotis Alexander J

Abstract excerpt

Mitochondrial fatty acid synthesis (mtFAS) shares acetyl-CoA with the Krebs cycle as a common substrate and is required for the production of octanoic acid (C8) precursors of lipoic acid (LA) in mitochondria. MtFAS is a conserved pathway essential for respiration. In a genetic screen in Saccharomyces cerevisiae designed to further elucidate the physiological role of mtFAS, we isolated mutants with defects in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24102902
DOI: 10.1111/mmi.12402
PMCID: PMC4153884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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