Article
Defects in mitochondrial fatty acid synthesis result in failure of multiple aspects of mitochondrial biogenesis in Saccharomyces cerevisiae.
Molecular microbiology - 1 Nov 2013
Kursu V A Samuli, Pietikäinen Laura P, Fontanesi Flavia, Aaltonen Mari J, Suomi Fumi, Raghavan Nair Remya, Schonauer Melissa S, Dieckmann Carol L, Barrientos Antoni, Hiltunen J Kalervo, Kastaniotis Alexander J
Abstract excerpt
Mitochondrial fatty acid synthesis (mtFAS) shares acetyl-CoA with the Krebs cycle as a common substrate and is required for the production of octanoic acid (C8) precursors of lipoic acid (LA) in mitochondria. MtFAS is a conserved pathway essential for respiration. In a genetic screen in Saccharomyces cerevisiae designed to further elucidate the physiological role of mtFAS, we isolated mutants with defects in...
Topics
- Acetyl Coenzyme A
- Caprylates
- Cell Respiration
- Citric Acid Cycle
- Fatty Acids
- Feedback, Physiological
- Gene Expression Regulation, Fungal
- Introns
- Lipoylation