Article
Toxicity and carcinogenicity of riddelliine following 13 weeks of treatment to rats and mice.
Toxicon : official journal of the International Society on Toxinology - 1 Aug 1994
Chan P C, Mahler J, Bucher J R, Travlos G S, Reid J B
Abstract excerpt
Toxicity studies of riddelliine, a member of a class of pyrrolizidine alkaloids, were conducted because riddelliine has been found to contaminate human food sources. Groups of male and female Fischer rats were administered riddelliine by gavage in phosphate buffer at doses up to 10 mg/kg, and B6C...
Topics
- Adenoma, Liver Cell
- Administration, Oral
- Animals
- Body Weight
- Carcinogens
- Cells, Cultured
- DNA
- Dose-Response Relationship, Drug
- Female
- Image Processing, Computer-Assisted
- Liver
- Liver Neoplasms
- Macrophages
- Male
- Mice
- Micronucleus Tests
- Microscopy, Fluorescence
- Mutation