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Article

Clinical value of direct DNA analysis of the RET proto-oncogene in families with multiple endocrine neoplasia type 2A.

Surgery - 1 Dec 1994

Feldman G L, Kambouris M, Talpos G B, Mulligan L M, Ponder B A, Jackson C E

Abstract excerpt

BACKGROUND: The multiple endocrine neoplasia type 2A gene is the RET proto-oncogene located on the long arm of chromosome 10, and many mutations within this gene have been reported. METHODS: Peripheral blood DNA was analyzed from 95 members of twelve families with multiple endocrine neoplasia type 2A and known mutations in codon 634 (of exon 11) of the RET proto-oncogene. This region was amplified by the...

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Identifiers

PMID: 7985085

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Clinical value of direct DNA analysis of the RET proto-oncogene in families with multiple endocrine neoplasia type 2A.PMID 7985085Read ↗

Predictive testing for multiple endocrine neoplasia type 2A (MEN 2A) based on the detection of mutations in the RET protooncogene.Semantic proximity Read ↗

Very early detection of <i>RET</i> proto‐oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 childrenSemantic proximity Read ↗

[The molecular pathology of RET protooncogene in families with multiple endocrine neoplasia type 2A].Semantic proximity Read ↗

Predictive DNA testing and prophylactic thyroidectomy in patients at risk for multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

[Early diagnosis of multiple endocrine neoplasia type 2 (MEN 2) by detection of mutated RET proto-oncogene carriers].Semantic proximity Read ↗

Multiple endocrine neoplasia type 2A. Study of a family.Semantic proximity Read ↗

Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B and FMTC: two novel mutations and one de novo mutation for MEN 2A.Semantic proximity Read ↗

A newly identified RET proto-oncogene polymorphism is found in a high number of endocrine tumor patients.Semantic proximity Read ↗

[Genetic analysis of RET mutations in families with multiple endocrine neoplasia type II in the community of Murcia].Semantic proximity Read ↗

Germ line mutation analysis in families with multiple endocrine neoplasia type 2A or familial medullary thyroid carcinoma.Semantic proximity Read ↗

Frequent RET protooncogene mutations in multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

Loss of heterozygosity at the RET protooncogene locus in a case of multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

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