Article
[Early diagnosis of multiple endocrine neoplasia type 2 (MEN 2) by detection of mutated RET proto-oncogene carriers].
Medicina - 1 Jan 1998
Sansó G, Domené H M, Iorcansky S, Barontini M
Abstract excerpt
RET proto-oncogene mutation results in a dominant autosomic inherited syndrome (MEN 2) presenting three distinct subtypes: MEN 2A, MEN 2B, and familial medullary thyroid carcinoma (FMTC). Detection of RET proto-oncogene mutation is a predictor before clinical or biochemical evidence of the diseas...
Topics
- Adult
- Carcinoma, Medullary
- Child
- DNA, Neoplasm
- Drosophila Proteins
- Female
- Humans
- Male
- Multiple Endocrine Neoplasia
- Multiple Endocrine Neoplasia Type 2a
- Multiple Endocrine Neoplasia Type 2b
- Mutation
- Pedigree
- Pheochromocytoma
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-ret
- Receptor Protein-Tyrosine Kinases