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Article

Early onset parkinsonism with diurnal fluctuation maps to a locus for juvenile parkinsonism.

Neurology - 1 May 1998

Matsumine H, Yamamura Y, Kobayashi T, Nakamura S, Kuzuhara S, Mizuno Y

Abstract excerpt

Early onset parkinsonism with diurnal fluctuation (EPDF) is a dopa-responsive parkinsonism characterized by early onset and improvement of parkinsonian symptoms after sleep. A pathologic study of one case of EPDF showed selective neuronal degeneration in the zona compacta of the substantia nigra...

Topics

Adolescent
Adult
Age of Onset
Child
Chromosome Mapping
Chromosomes, Human, Pair 6
Circadian Rhythm
Genetic Linkage
Haplotypes
Humans
Lod Score
Parkinson Disease
Pedigree

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Identifiers

PMID: 9595984
DOI: 10.1212/wnl.50.5.1340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9595984-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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