Article
Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites.
Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Jan 2000
Babiker H, Ranford-Cartwright L, Sultan A, Satti G, Walliker D
Abstract excerpt
Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in...
Topics
- Alleles
- Animals
- Chloroquine
- Drug Resistance
- Humans
- Malaria, Falciparum
- Plasmodium falciparum
- Polymerase Chain Reaction
- Recurrence