Article
Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer.
Molecular and cellular biology - 1 Nov 1998
Guerrette S, Wilson T, Gradia S, Fishel R
Abstract excerpt
Mutations in the human mismatch repair protein hMSH2 have been found to cosegregate with hereditary nonpolyposis colorectal cancer (HNPCC). Previous biochemical and physical studies have shown that hMSH2 forms specific mispair binding complexes with hMSH3 and hMSH6. We have further characterized...
Topics
- Binding Sites
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair
- DNA-Binding Proteins
- Dimerization
- Humans
- Multidrug Resistance-Associated Proteins
- MutS Homolog 2 Protein
- MutS Homolog 3 Protein
- Mutagenesis
- Mutation
- Protein Binding
- Proto-Oncogene Proteins
- Recombinant Fusion Proteins