Article
Evaluation of a live attenuated recombinant virus RAV 9395 as a herpes simplex virus type 2 vaccine in guinea pigs.
The Journal of infectious diseases - 1 May 1998
Spector F C, Kern E R, Palmer J, Kaiwar R, Cha T A, Brown P, Spaete R R
Abstract excerpt
Recombinant virus RAV 9395 was constructed by deleting both copies of the gamma(1)34.5 gene, and the UL55 and UL56 open reading frames from herpes simplex virus type 2 (HSV-2) strain G. The potential use of RAV 9395 as an HSV-2 vaccine was investigated by evaluating the ability of RAV 9395 to pro...
Topics
- Animals
- Cell Line
- Chlorocebus aethiops
- DNA, Viral
- Female
- Gene Deletion
- Genome, Viral
- Genotype
- Guinea Pigs
- Herpes Genitalis
- Herpesvirus 2, Human
- Humans
- Kidney
- Open Reading Frames
- Phenotype
- Rabbits
- Vaccines, Attenuated
- Vaccines, Synthetic