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Article

Formylation is not essential for initiation of protein synthesis in all eubacteria.

The Journal of biological chemistry - 6 Aug 1999

Newton D T, Creuzenet C, Mangroo D

Abstract excerpt

Formylation of the initiator methionyl-tRNA, catalyzed by methionyl-tRNA formyltransferase, has long been regarded as essential for initiation of protein synthesis in eubacteria. Here, we show that this process is, in fact, dispensable in Pseudomonas aeruginosa. Disruption of the chromosomal methionyl-tRNA formyltransferase gene in P. aeruginosa resulted only in a moderate decrease in the rate of cell growth,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10428776
DOI: 10.1074/jbc.274.32.22143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Formylation is not essential for initiation of protein synthesis in all eubacteria.PMID 10428776Read ↗

Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli.Semantic proximity Read ↗

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Initiation of in vivo protein synthesis with non-methionine amino acids.Semantic proximity Read ↗

Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase.Semantic proximity Read ↗

Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli.Semantic proximity Read ↗

Important role of the amino acid attached to tRNA in formylation and in initiation of protein synthesis in Escherichia coli.Semantic proximity Read ↗

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