Article
Asbestos and erionite fibres can induce mutations in human lymphocytes that result in loss of heterozygosity.
International journal of cancer - 15 Nov 1994
Both K, Henderson D W, Turner D R
Abstract excerpt
Although asbestos and erionite are proven human carcinogens, most studies have concluded that these fibres are not mutagenic to mammalian cells in vitro. We have studied the potential of these fibres and chrysotile fibres to induce mutations in human peripheral lymphocytes, using a mutation assay...
Topics
- Alleles
- Asbestos, Crocidolite
- Asbestos, Serpentine
- Cells, Cultured
- Chi-Square Distribution
- Chromosome Deletion
- Chromosomes, Human, Pair 6
- Cloning, Molecular
- Gene Deletion
- Genes, MHC Class I
- HLA-A Antigens
- Heterozygote
- Humans
- Lymphocytes
- Mutagenesis, Site-Directed
- Mutagenicity Tests
- Polymorphism, Restriction Fragment Length
- Repetitive Sequences, Nucleic Acid