Article
Constitutive sensory transduction mutations in the Bordetella pertussis bvgS gene.
Journal of bacteriology - 1 Feb 1992
Miller J F, Johnson S A, Black W J, Beattie D T, Mekalanos J J, Falkow S
Abstract excerpt
The products of the bvgAS locus coordinately regulate expression of the Bordetella pertussis virulence regulon in response to environmental signals. Transcription of bvgAS-activated genes is nearly eliminated by several modulating conditions, including the presence of sulfate anion or nicotinic acid and growth at low temperature. We have isolated spontaneous mutations that result in the constitutive synthesis of...
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