Article
Recombinant thyrotropin receptor and the induction of autoimmune thyroid disease in BALB/c mice: a new animal model.
Endocrinology - 1 Nov 1994
Costagliola S, Many M C, Stalmans-Falys M, Tonacchera M, Vassart G, Ludgate M
Abstract excerpt
In a preliminary study, we observed the production of TSH binding-inhibiting (TBII) and thyroid-blocking (TBAb) antibodies accompanied by lymphocytic infiltration of the thyroid in a pool of male BALB/c mice immunized with the extracellular domain (ECD) of the human TSH receptor (TSHR) expressed...
Topics
- Animals
- Cell Movement
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Female
- Immunoglobulin G
- Immunoglobulins, Thyroid-Stimulating
- Immunohistochemistry
- Lymphocytes
- Male
- Mice
- Mice, Inbred BALB C
- Phenotype
- Receptors, Thyrotropin
- Recombinant Proteins
- Thyroiditis, Autoimmune
- Thyroxine