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Article

Structure-function relationships in the tissue inhibitors of metalloproteinases.

American journal of respiratory and critical care medicine - 1 Dec 1994

Willenbrock F, Murphy G

Abstract excerpt

The tissue inhibitors of metalloproteinases (TIMPs) are proteins that specifically inhibit the matrix metalloproteinases. They consist of two distinct structural and functional domains. In order to elucidate the role of these domains, we have prepared mutants of TIMP-1 and TIMP-2 that lack a C-terminal domain. The N-terminal domain alone is an efficient inhibitor of all the matrix metalloproteinases through...

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PMID: 7952654
DOI: 10.1164/ajrccm/150.6_Pt_2.S165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Structure-function relationships in the tissue inhibitors of metalloproteinases.PMID 7952654Read ↗

Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.Semantic proximity Read ↗

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversitySemantic proximity Read ↗

The Matrix Metalloproteinases and Their InhibitorsSemantic proximity Read ↗

Protein engineering of the tissue inhibitor of metalloproteinase 1 (TIMP-1) inhibitory domain. In search of selective matrix metalloproteinase inhibitors.Semantic proximity Read ↗

The Specificity of TIMP-2 for Matrix Metalloproteinases Can Be Modified by Single Amino Acid MutationsSemantic proximity Read ↗

Matrix Metalloproteinases: New Directions Toward Inhibition in the Fight Against CancersSemantic proximity Read ↗

Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzyme.Semantic proximity Read ↗

The Role of Tissue Inhibitors of Metalloproteinases in Tumorigenesis and MetastasisSemantic proximity Read ↗

The TIMP protein family: diverse roles in pathophysiologySemantic proximity Read ↗

Threonine 98, the pivotal residue of tissue inhibitor of metalloproteinases (TIMP)-1 in metalloproteinase recognition.Semantic proximity Read ↗

The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3.Semantic proximity Read ↗

Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP ComplexesSemantic proximity Read ↗

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