Structure-function relationships in the tissue inhibitors of metalloproteinases.

doi:10.1164/ajrccm/150.6_Pt_2.S165

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Article

Structure-function relationships in the tissue inhibitors of metalloproteinases.

American journal of respiratory and critical care medicine - 1 Dec 1994

Willenbrock F, Murphy G

Abstract excerpt

The tissue inhibitors of metalloproteinases (TIMPs) are proteins that specifically inhibit the matrix metalloproteinases. They consist of two distinct structural and functional domains. In order to elucidate the role of these domains, we have prepared mutants of TIMP-1 and TIMP-2 that lack a C-te...

Topics

Amino Acid Sequence
Binding Sites
Binding, Competitive
Gelatinases
Glycoproteins
Humans
Kinetics
Matrix Metalloproteinase 2
Matrix Metalloproteinase 7
Metalloendopeptidases
Molecular Sequence Data
Mutation
Structure-Activity Relationship
Tissue Inhibitor of Metalloproteinases

Source

Open in PubMed

Identifiers

PMID: 7952654
DOI: 10.1164/ajrccm/150.6_Pt_2.S165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7952654-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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