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The Matrix Metalloproteinases and Their Inhibitors

1 Aug 1992

Abstract excerpt

A number of metalloproteinases that degrade the extracellular matrix of connective tissues and two specific tissue inhibitors of metalloproteinases (TIMPs) have now been isolated, characterized, and cloned. Comparison of the enzyme sequences has allowed the delineation of domain structures, and initial studies have been carried out to assess the contribution of these domains to their biochemical and biologic...

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Identifiers

PMID: 1497900
DOI: 10.1165/ajrcmb/7.2.120

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