Altered conformation and increased strand breaks in neuronal and astroglial DNA of aging rat brain.

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Article

Altered conformation and increased strand breaks in neuronal and astroglial DNA of aging rat brain.

Biochemistry and molecular biology international - 1 May 1994

Bhaskar M S, Rao K S

Abstract excerpt

Melting temperatures (Tm) of the DNA isolated from young, adult, and old rat brain neurons and astrocytes were recorded under different conditions. There was a rise in Tm and decrease in hyperchromicity in the old when compared to the young and adult. Single and double strand breaks were assessed...

Topics

Aging
Animals
Astrocytes
Cerebral Cortex
DNA
DNA Damage
DNA, Single-Stranded
Electrophoresis, Agar Gel
Genetic Techniques
Mutation
Neurons
Nucleic Acid Conformation
Rats
Rats, Wistar
Single-Strand Specific DNA and RNA Endonucleases

Source

Open in PubMed

Identifiers

PMID: 7951055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7951055-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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