Article
Altered conformation and increased strand breaks in neuronal and astroglial DNA of aging rat brain.
Biochemistry and molecular biology international - 1 May 1994
Bhaskar M S, Rao K S
Abstract excerpt
Melting temperatures (Tm) of the DNA isolated from young, adult, and old rat brain neurons and astrocytes were recorded under different conditions. There was a rise in Tm and decrease in hyperchromicity in the old when compared to the young and adult. Single and double strand breaks were assessed by using nick translation type incubation of DNA with E. coli Pol I and addition of nucleotides at the terminal 3'-OH...
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