Regulation of intracellular pH during oocyte growth and maturation in mammals

Abstract excerpt

Regulation of intracellular pH (pH(i)) is a fundamental homeostatic process essential for the survival and proliferation of virtually all cell types. The mammalian preimplantation embryo, for example, possesses Na(+)/H(+) and HCO(3)(-)/Cl(-) exchangers that robustly regulate against acidosis and alkalosis respectively. Inhibition of these transporters prevents pH corrections and, perhaps unsurprisingly, leads to...

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