Extracellular protons reduce quantal content and prolong synaptic currents at the Drosophila larval neuromuscular junction.

doi:10.3109/01677063.2011.606577

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Article

Extracellular protons reduce quantal content and prolong synaptic currents at the Drosophila larval neuromuscular junction.

Journal of neurogenetics - 1 Oct 2011

Sandstrom David J

Abstract excerpt

Fluctuations in extracellular pH occur in the nervous system in response to a number of physiological and pathological processes, such as ischemia, hypercapnea, and high-frequency activity. Using the Drosophila larval neuromuscular junction, the author has examined acute effects of low and high pH on excitability and synaptic transmission. Acidification rapidly and reversibly reduces the size of electrically...

Topics

Analysis of Variance
Animals
Animals, Genetically Modified
Biophysical Phenomena
Biophysics
Drosophila
Drosophila Proteins
Electric Stimulation
Extracellular Fluid
Glutamic Acid
Hydrogen-Ion Concentration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Vitro Techniques

Large-Conductance Calcium-Activated Potassium Channels

Larva

Mutation

Neuromuscular Junction

Protons

Reaction Time

Source

Open in PubMed Open full text

Identifiers

PMID: 21877902
DOI: 10.3109/01677063.2011.606577
PMCID: PMC3462067

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